Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena

被引:9
作者
Fraulob, M. [1 ]
Vayron, R. [2 ]
Le Cann, S. [1 ]
Lecuelle, B. [3 ]
Heriveaux, Y. [1 ]
Lomami, H. Albini [1 ]
Lachaniette, C. H. Flouzat [4 ,5 ]
Haiat, G. [1 ]
机构
[1] Univ Gustave Eiffel, Univ Paris Est Creteil, CNRS, MSME,UMR 8208, 61 Ave Gen Gaulle, F-94010 Creteil, France
[2] Univ Polytech Hauts France, CNRS, Lab Automat Mecan & Informat Ind & Humaines, LAMIH,UMR 8201, F-59300 Valenciennes, France
[3] Ecole Natl Vet Alfort, Ctr Rech BioMed, 7 Ave Gen Gaulle, F-94700 Maisons Alfort, France
[4] Univ Paris Est, INSERM, IMRB, U955, 51 Ave Marechal Lattre Tassigny, F-94000 Creteil, France
[5] Univ Paris Est, CHU Paris 12, Hop Henri Mondor, AP HP,Serv Chirurg Orthoped & Traumatol, 51 Ave Marechal Lattre Tassigny, F-94000 Creteil, France
基金
欧洲研究理事会; 欧盟地平线“2020”;
关键词
BONE-IMPLANT INTERFACE; DENTAL IMPLANT; TITANIUM IMPLANT; BIOMECHANICAL STABILITY; WAVE-PROPAGATION; ATTACHMENT; REFLECTION; SIMULATION;
D O I
10.1038/s41598-020-78806-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The evolution of bone tissue quantity and quality in contact with the surface of orthopedic and dental implants is a strong determinant of the surgical outcome but remains difficult to be assessed quantitatively. The aim of this study was to investigate the performance of a quantitative ultrasound (QUS) method to measure bone-implant interface (BII) properties. A dedicated animal model considering coin-shaped titanium implants with two levels of surface roughness (smooth, S-a=0.49 mu m and rough, S-a=3.5 mu m) allowed to work with a reproducible geometry and a planar interface. The implants were inserted in rabbit femurs and tibiae for 7 or 13 weeks. The ultrasonic response of the BII was measured ex vivo, leading to the determination of the 2-D spatial variations of bone in contact with the implant surface. Histological analysis was carried out to determine the bone-implant contact (BIC) ratio. The amplitude of the echo was significantly higher after 7 weeks of healing time compared to 13 weeks, for both smooth (p<0.01) and rough (p<0.05) implants. A negative correlation (R=-0.63) was obtained between the ultrasonic response and the BIC. This QUS technique is more sensitive to changes of BII morphology compared to histological analyses.
引用
收藏
页数:12
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