Biotin

被引：254

作者：

Zempleni, Janos ^{[1
]}

Wijeratne, Subhashinee S. K. ^{[1
]}

Hassan, Yousef I. ^{[1
]}

机构：

[1] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA

来源：

BIOFACTORS | 2009年 / 35卷 / 01期

关键词：

Biotin; biotinidase; deficiency; holocarboxylase synthetase; metabolism; transport; PROPIONYL-COA CARBOXYLASE; HUMAN SERUM BIOTINIDASE; HOLOCARBOXYLASE SYNTHETASE; INTESTINAL-ABSORPTION; HISTONE BIOTINYLATION; GENE-EXPRESSION; 3-HYDROXYISOVALERIC ACID; DROSOPHILA-MELANOGASTER; URINARY-EXCRETION; FATTY-ACID;

D O I：

10.1002/biof.8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biotin is a water-soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins Such as holdcarboxylase synthetase, biotinidase and the biotin transporters SMVT and MCT1 play crucial roles in biotin homeostasis, and these roles are reviewed here. Possible effects of inadequate biotin intake, drug interactions, and inborn errors of metabolism are discussed, including putative effects on birth defects. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 36-46. E-mail: jzempleni2@unl.edu

引用

页码：36 / 46

页数：11

共 113 条

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