Biotin

被引：254
作者：
Zempleni, Janos [1 ]
Wijeratne, Subhashinee S. K. [1 ]
Hassan, Yousef I. [1 ]
机构：
[1] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA
来源：
BIOFACTORS | 2009年 / 35卷 / 01期
关键词：
Biotin; biotinidase; deficiency; holocarboxylase synthetase; metabolism; transport; PROPIONYL-COA CARBOXYLASE; HUMAN SERUM BIOTINIDASE; HOLOCARBOXYLASE SYNTHETASE; INTESTINAL-ABSORPTION; HISTONE BIOTINYLATION; GENE-EXPRESSION; 3-HYDROXYISOVALERIC ACID; DROSOPHILA-MELANOGASTER; URINARY-EXCRETION; FATTY-ACID;
D O I：
10.1002/biof.8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biotin is a water-soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins Such as holdcarboxylase synthetase, biotinidase and the biotin transporters SMVT and MCT1 play crucial roles in biotin homeostasis, and these roles are reviewed here. Possible effects of inadequate biotin intake, drug interactions, and inborn errors of metabolism are discussed, including putative effects on birth defects. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 36-46. E-mail: jzempleni2@unl.edu
引用
收藏
页码：36 / 46
页数：11
相关论文
共 113 条
  • [1] Biotin deficiency blocks thymocyte maturation, accelerates thymus involution, and decreases nose-rump length in mice
    Báez-Saldaña, A
    Ortega, E
    [J]. JOURNAL OF NUTRITION, 2004, 134 (08) : 1970 - 1977
  • [2] Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice
    Báez-Saldaña, A
    Díaz, G
    Espinoza, B
    Ortega, E
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 67 (03) : 431 - 437
  • [3] Biotinidase catalyzes debiotinylation of histones
    Ballard, TD
    Wolff, J
    Griffin, JB
    Stanley, JS
    van Calcar, S
    Zempleni, J
    [J]. EUROPEAN JOURNAL OF NUTRITION, 2002, 41 (02) : 78 - 84
  • [4] Isolated 3-methylcrotonyl-CoA carboxylase deficiency: Evidence for an allele-specific dominant negative effect and responsiveness to biotin therapy
    Baumgartner, MR
    Dantas, MF
    Suormala, T
    Almashanu, S
    Giunta, C
    Friebel, D
    Gebhardt, B
    Fowler, B
    Hoffmann, GF
    Baumgartner, ER
    Valle, D
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (05) : 790 - 800
  • [5] The effect of desiccation upon the nutritive properties of egg-white.
    Boas, MA
    [J]. BIOCHEMICAL JOURNAL, 1927, 21 (03) : 712 - U7
  • [6] INTESTINAL-ABSORPTION OF BIOTIN IN THE RAT
    BOWMAN, BB
    SELHUB, J
    ROSENBERG, IH
    [J]. JOURNAL OF NUTRITION, 1986, 116 (07) : 1266 - 1271
  • [7] BIOTIN ABSORPTION BY DISTAL RAT INTESTINE
    BOWMAN, BB
    ROSENBERG, IH
    [J]. JOURNAL OF NUTRITION, 1987, 117 (12) : 2121 - 2126
  • [8] K8 and K12 are biotinylated in human histone H4
    Camporeale, G
    Shubert, EE
    Sarath, G
    Cerny, R
    Zempleni, J
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (11): : 2257 - 2263
  • [9] Camporeale G., 2006, PRESENT KNOWLEDGE NU, V9th, P314
  • [10] K12-biotinylated histone H4 marks heterochromatin in human lymphoblastoma cells
    Camporeale, Gabriela
    Oommen, Anna M.
    Griffin, Jacob B.
    Sarath, Gautam
    Zempleni, Janos
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2007, 18 (11) : 760 - 768
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