Testican 3 expression in adult T-cell leukemia

被引：15

作者：

Kamioka, Mikio ^{[1
]}

Imamura, Jun ^{[2
]}

Komatsu, Naoki ^{[3
]}

Daibata, Masanori ^{[3
]}

Sugiura, Tetsuro ^{[1
]}

机构：

[1] Kochi Univ, Dept Lab Med, Kochi 7838505, Japan

[2] Kochi Univ, Dept Transfus Med, Kochi 7838505, Japan

[3] Kochi Univ, Dept Hematol & Resp Med, Kochi 7838505, Japan

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 07期

关键词：

Adult T-cell leukemia; Human T-lymphotropic virus type I; Activating transcriptional factor 3; Testican; 3; VIRUS TYPE-I; ACTIVATING TRANSCRIPTION FACTOR-3; MATRIX METALLOPROTEINASES; ANTIBODIES; GENE; ATF3; SUPPRESSION; INDUCER; EMMPRIN; DISEASE;

D O I：

10.1016/j.leukres.2008.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adult T-cell leukemia (ATL) is an aggressive disease characterized by visceral invasion, and ATL regulates matrix metalloproteinase (MMP) activities of the endothelial cells. The controlling system of MMP activities in ATL is regulated by various factors such as Emmprin and tissue inhibitor of MMP. In this study, we demonstrated that Testican 3 expression in ATL decreased the activity of MMP. Furthermore, we showed that the expression of Testican 3 was regulated by activating transcriptional factor 3 in human T-lymphotropic virus type I-related cell lines. Thus, Testican 3 is a novel regulator to reduce the activity of MMP in ATL (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：913 / 918

页数：6

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