Effects of adrenomedullin on rat cerebral arterioles

被引：25
作者：
Mori, Y
Takayasu, M
Suzuki, Y
Shibuya, M
Yoshida, J
Hidaka, H
机构：
[1] NAGOYA UNIV,SCH MED,DEPT NEUROSURG,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NAGOYA UNIV,SCH MED,DEPT PHARMACOL,NAGOYA,AICHI 466,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 330卷 / 2-3期
关键词：
adrenomedullin; CGRP (calcitonin gene-related peptide); CGRP-(8-37); amylin; cerebral arteriole; cerebral microcirculation;
D O I：
10.1016/S0014-2999(97)01028-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of adrenomedullin on isolated rat intracerebral arterioles were investigated and compared with those of calcitonin gene-related peptide (CGRP) and amylin. Adrenomedullin produced dose-dependent vasodilation (maximum dilation 27.1 +/- 2.1% at 3 x 10(-7) M, median effective dose (EC50) 1.6 x 10(-9) M). CGRP produced similar vasodilation (19.8 +/- 4.1%) at 10(-7) M with a lower EC50 of 2.8 x 10(-11) M. Amylin did not cause vasodilation at concentrations up to 10(-6) M. Adrenomedullin-induced vasodilation was significantly suppressed by CGRP-(8-37). These data suggest that adrenomedullin is a potent vasodilator for arterioles in the cerebral microcirculation that acts through CGRP receptors. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：195 / 198
页数：4
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