A personalized view on cancer immunotherapy

被引：55
作者：
Wayteck, Laura [1 ]
Breckpot, Karine [2 ]
Demeester, Jo [1 ]
De Smedt, Stefaan C. [1 ]
Raemdonck, Koen [1 ]
机构：
[1] Univ Ghent, Lab Gen Biochem & Phys Pharm, Fac Pharmaceut Sci, B-9000 Ghent, Belgium
[2] Vrije Univ Brussel, Lab Mol & Cellular Therapy, Dept Immunol & Physiol, Sch Med, B-1090 Brussels, Belgium
来源：
CANCER LETTERS | 2014年 / 352卷 / 01期
关键词：
Cancer immunotherapy; Personalized medicine; Tumor antigens; Predictive biomarkers; Tumor heterogeneity; Adoptive T cell therapy; CHIMERIC-ANTIGEN-RECEPTOR; CD8(+) T-CELLS; ACUTE MYELOID-LEUKEMIA; IMMUNOSTIMULATORY MONOCLONAL-ANTIBODIES; TUMOR-INFILTRATING LYMPHOCYTES; DENDRITIC CELLS; MESSENGER-RNA; METASTATIC MELANOMA; CANCER/TESTIS ANTIGENS; ADOPTIVE IMMUNOTHERAPY;
D O I：
10.1016/j.canlet.2013.09.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent progress in cancer immunotherapy has resulted in complete responses in patients refractory to current standard cancer therapies. However, due to tumor heterogeneity and inter-individual variations in anti-tumor immunity, only subsets of patients experience clinical benefit. This review highlights the implementation of a personalized approach to enhance treatment efficacy and reduce side effects, including the identification of tumor-specific antigens for cancer vaccination and adoptive T cell therapies. Furthermore, together with the current advances and promising clinical outcomes of combination cancer (immuno-)therapies, the screening for predictive biomarkers in a patient-specific manner is emphasized. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：113 / 125
页数：13
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