Differential activity pattern of c-Fos in the nucleus accumbens between adult and aged rats during flavor recognition memory

被引：7
作者：
Grau-Perales, A. B. [1 ]
Gomez-Chacon, B. [1 ]
Gallo, M. [1 ]
机构：
[1] Univ Granada, Ctr Biomed Res CIBM, Inst Neurosci, Dept Psychobiol, Granada, Spain
来源：
BEHAVIOURAL BRAIN RESEARCH | 2019年 / 371卷
关键词：
Accumbens; Aging; Attenuation of neophobia; Flavor; c-Fos; Recognition memory; Taste; PERIRHINAL CORTEX; TASTE NEOPHOBIA; DOPAMINE TRANSMISSION; INSULAR CORTEX; FOOD-STIMULI; EXPRESSION; HIPPOCAMPUS; LESIONS; RESPONSIVENESS; HABITUATION;
D O I：
10.1016/j.bbr.2019.111935
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Previous studies have addressed the role of the nucleus accumbens core (NAcbC) and shell (NAcbSh) in taste aversion learning and in the processing of taste palatability which is affected by aging. However, little is known about its implication in safe taste memory and the aging impact. To explore the role of the NAcb in flavor neophobia and its attenuation during aging, we applied c-Fos immunohistochemistry as an index of neural activity of the NAcbC and NAcbSh. Twenty one adult (5-month-old) and 24 aged (24-month-old) male Wistar rats were exposed to a 3% cider vinegar solution for 1, 2 or 6 consecutive days (n = 7 adult and n = 8 aged rats per group). Aged rats exhibited slower attenuation of flavor neophobia than adult rats. Adult rats showed increased NAcbSh c-Fos activity on day 2 compared to days 1 and 6, while this increase was delayed to day 6 in aged rats. There were no differences in the number of NAcbC c-Fos positive cells. This suggests that changes in the activity of neural circuits of palatability processing during normal aging could contribute to the slower attenuation of flavor neophobia in aged rats.
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页数：6
相关论文
共 30 条
[1]   Neural signature of taste familiarity in the gustatory cortex of the freely behaving rat [J].
Bahar, A ;
Dudai, Y ;
Ahissar, E .
JOURNAL OF NEUROPHYSIOLOGY, 2004, 92 (06) :3298-3308
[2]   Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory [J].
Balderas, Israela ;
Morin, Jean-Pascal ;
Rodriguez-Ortiz, Carlos J. ;
Bermudez-Rattoni, Federico .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2012, 97 (04) :418-424
[3]   Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex [J].
Bassareo, V ;
De Luca, MA ;
Di Chiar, G .
JOURNAL OF NEUROSCIENCE, 2002, 22 (11) :4709-4719
[4]  
Bassareo V, 1997, J NEUROSCI, V17, P851
[5]   Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments [J].
Bassareo, V ;
Di Chiara, G .
NEUROSCIENCE, 1999, 89 (03) :637-641
[6]   Molecular mechanisms of taste-recognition memory [J].
Bermúdez-Rattoni, F .
NATURE REVIEWS NEUROSCIENCE, 2004, 5 (03) :209-217
[7]   The forgotten insular cortex: Its role on recognition memory formation [J].
Bermudez-Rattoni, Federico .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2014, 109 :207-216
[8]   Memory is differently impaired during aging according to the learning tasks in the rat [J].
Dardou, David ;
Datiche, Frederique ;
Cattarelli, Martine .
BEHAVIOURAL BRAIN RESEARCH, 2008, 194 (02) :193-200
[9]   Medial temporal lobe structures participate differentially in consolidation of safe and aversive taste memories [J].
De la Cruz, Vanesa ;
Rodriguez-Ortiz, Carlos J. ;
Balderas, Israela ;
Bermudez-Rattoni, Federico .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 28 (07) :1377-1381
[10]   A role for dopamine D1 receptors of the nucleus accumbens shell in conditioned taste aversion learning [J].
Fenu, S ;
Bassareo, V ;
Di Chiara, G .
JOURNAL OF NEUROSCIENCE, 2001, 21 (17) :6897-6904
123