Improved survival with rituximab-based chemoimmunotherapy in older patients with extranodal diffuse large B-cell lymphoma

被引：22

作者：

Olszewski, Adam J. ^{[1
]}

Winer, Eric S. ^{[2
]}

Castillo, Jorge J. ^{[3
]}

机构：

[1] Brown Univ, Mem Hosp Rhode Isl, Ctr Canc, Pawtucket, RI 02860 USA

[2] Rhode Isl Hosp, Div Hematol & Oncol, Providence, RI 02903 USA

[3] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02215 USA

来源：

LEUKEMIA RESEARCH | 2014年 / 38卷 / 08期

关键词：

Diffuse large B-cell lymphoma; R-CHOP chemotherapy; Rituximab; SEER program; Comparative effectiveness researcha; ELDERLY-PATIENTS; DES-LYMPHOMES; UNITED-STATES; MYD88; CHOP; CHEMOTHERAPY; ERA; MACROGLOBULINEMIA; INVOLVEMENT; POPULATION;

D O I：

10.1016/j.leukres.2014.04.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare database, we investigated the relative benefits of adding rituximab to CHOP chemotherapy in diffuse large B-cell lymphoma (DLBCL) of extranodal origin, and found similar advantage for nodal and extranodal lymphomas. Hazard ratio for overall survival was 0.64 for nodal, and 0.70 for extranodal DLBCL. Hazard ratios for lymphoma-related death were 0.62 and 0.57, respectively. The advantage was largest for DLBCL of the spleen, liver and lung. Conversely, it was not evident for thyroid or testicular lymphomas. Compared with nodal DLBCL, spleen was the only site with significantly better prognosis after R-CHOP. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：866 / 873

页数：8

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