Synthesis and antinociceptive activity of (1-benzyl-2(3H)-benzimidazolon-3-yl) acetic acid derivatives

被引：10

作者：

Nacak, S ^{[1
]}

Dogruer, DS ^{[1
]}

Sahin, MF ^{[1
]}

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

2(3H)-benzimidazolone derivatives; antinociceptive activity;

D O I：

10.1016/S0014-827X(99)00100-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eight (1-benzyl-2(3H)-benzimidazolon-3-yl)acetic acid derivatives have been synthesized and tested for antinociceptive activity in this study. All compounds but one, at the oral dose of 100 mg/kg were comparable with aspirin. Ethyl (1-benzyl-2(3H)-benzimidazolon-3-yl)acetate (3), 4-[(1-benzyl-2(3H)-benzimidazolon-3-yl)acetyl]morpholine (6a) and 1-[(1-benzyl-2(3H)-benzimidazolon-3-yl)acetyl]pyrrolidine (6b) have shown more potent antinociceptive activity than others. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：768 / 772

页数：5

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