Epigenetic epidemiology: Promises for public health research

被引：77

作者：

Bakulski, Kelly M. ^{[1
,2
]}

Fallin, M. Daniele ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Ctr Excellence Genom Sci, Baltimore, MD USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Wendy Klag Ctr Autism & Dev Disabil, Baltimore, MD USA

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2014年 / 55卷 / 03期

关键词：

DNA methylation; environment; epigenetics; disease; epidemiology; DIFFERENTIAL DNA METHYLATION; LYMPHOBLASTOID CELL-LINES; HIGH-THROUGHPUT ANALYSIS; 5-HT2A RECEPTOR GENE; BIPOLAR DISORDER; TRANSGENERATIONAL INHERITANCE; MENDELIAN RANDOMIZATION; GENOMIC STABILITY; DIETARY EXPOSURE; TWIN DISCORDANCE;

D O I：

10.1002/em.21850

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Epigenetic changes underlie developmental and age related biology. Promising epidemiologic research implicates epigenetics in disease risk and progression, and suggests epigenetic status depends on environmental risks as well as genetic predisposition. Epigenetics may represent a mechanistic link between environmental exposures, or genetics, and many common diseases, or may simply provide a quantitative biomarker for exposure or disease for areas of epidemiology currently lacking such measures. This great promise is balanced by issues related to study design, measurement tools, statistical methods, and biological interpretation that must be given careful consideration in an epidemiologic setting. This article describes the promises and challenges for epigenetic epidemiology, and suggests directions to advance this emerging area of molecular epidemiology. Environ. Mol. Mutagen. 55:171-183, 2014. (c) 2014 Wiley Periodicals, Inc.

引用

页码：171 / 183

页数：13

共 156 条

[1] Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 [J].