Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

被引:118
作者
Battistini, Carolina [1 ,2 ]
Ballan, Rafael [1 ,2 ]
Herkenhoff, Marcos Edgar [1 ,2 ]
Saad, Susana Marta Isay [1 ,2 ]
Sun, Jun [3 ,4 ]
机构
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut & Biochem Technol, Ave Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Food Res Ctr, Rua Lago 250, BR-05508080 Sao Paulo, SP, Brazil
[3] Univ Illinois, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL 60612 USA
[4] Univ Illinois, UIC Canc Ctr, Dept Microbiol & Immunol, Chicago, IL 60612 USA
基金
巴西圣保罗研究基金会; 美国国家卫生研究院;
关键词
antimicrobial peptides (AMP); Crohn's disease; dysbiosis; epigenetics; inflammation; metabolites; microbiome; micronutrient; nuclear receptor; probiotics; tight junctions; ulcerative colitis; vitamin D; VDR; D-RECEPTOR; CROHNS-DISEASE; ULCERATIVE-COLITIS; GUT MICROBIOTA; 1,25-DIHYDROXYVITAMIN D-3; ALTERED EXPRESSION; PEDIATRIC-PATIENTS; BARRIER FUNCTION; GENE-EXPRESSION; PROTECTS MICE;
D O I
10.3390/ijms22010362
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT), including Crohn's disease (CD) and ulcerative colitis (UC), which differ in the location and lesion extensions. Both diseases are associated with microbiota dysbiosis, with a reduced population of butyrate-producing species, abnormal inflammatory response, and micronutrient deficiency (e.g., vitamin D hypovitaminosis). Vitamin D (VitD) is involved in immune cell differentiation, gut microbiota modulation, gene transcription, and barrier integrity. Vitamin D receptor (VDR) regulates the biological actions of the active VitD (1 alpha,25-dihydroxyvitamin D3), and is involved in the genetic, environmental, immune, and microbial aspects of IBD. VitD deficiency is correlated with disease activity and its administration targeting a concentration of 30 ng/mL may have the potential to reduce disease activity. Moreover, VDR regulates functions of T cells and Paneth cells and modulates release of antimicrobial peptides in gut microbiota-host interactions. Meanwhile, beneficial microbial metabolites, e.g., butyrate, upregulate the VDR signaling. In this review, we summarize the clinical progress and mechanism studies on VitD/VDR related to gut microbiota modulation in IBD. We also discuss epigenetics in IBD and the probiotic regulation of VDR. Furthermore, we discuss the existing challenges and future directions. There is a lack of well-designed clinical trials exploring the appropriate dose and the influence of gender, age, ethnicity, genetics, microbiome, and metabolic disorders in IBD subtypes. To move forward, we need well-designed therapeutic studies to examine whether enhanced vitamin D will restore functions of VDR and microbiome in inhibiting chronic inflammation.
引用
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页码:1 / 22
页数:22
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