Up-regulation of a serine-threonine kinase protooncogene Pim-1 in oral squamous cell carcinoma

被引：38
作者：
Chiang, W. -F.
Yen, C. -Y.
Lin, C. -N.
Liaw, G. -A.
Chiu, C. -T.
Hsia, Y. -J.
Liu, S. -Y. [1 ]
机构：
[1] Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg, Tainan, Taiwan
[2] Chi Mei Hosp, Dept Oral & Maxillofacial Surg, Liouying, Taiwan
[3] Taipei Med Univ, Coll Oral Med, Dept Dent, Taipei, Taiwan
[4] Natl Def Med Ctr, Sch Dent, Taipei, Taiwan
[5] Chang Gung Mem Hosp, Dept Oral & Maxillofacial Surg, Kaohsiung, Taiwan
来源：
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2006年 / 35卷 / 08期
关键词：
oral cancer; Pim-1;
D O I：
10.1016/j.ijom.2006.01.027
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The Pim-1 proto-oncogene, encoding a serine-threonine kinase, has been found to play an important role in regulating apoptosis, differentiation, proliferation and tumourigenesis. The present study was conducted to assess the importance of Pim-1 in oral tumourigenesis in vivo. Reverse transcriptase-polymerase chain reaction and immunohistochemistry were used to study the expression of Pim-1 in oral squamous cell carcinoma (OSCC) and non-cancerous match tissue (NCMT) sampled from the periphery of the tumours. Pim-1 mRNA expression in OSCC was significantly higher than that in NCMT in 36 tissue pairs (1.33 +/- 0.41 versus 0.97 +/- 0.29, P = 0.03). The percentage of OSCCs exhibiting strong cytoplasmic Pim-1 immunoreactivity was significantly higher than that of NCMT (60% versus 19%, P = 0.007). Pim-1 immunoreactivity is higher in the more differentiated components of a tumour. In around 10% of OSCC cases, Pim-1 immunoreactivity was found in the nucleus as well. These results show novel findings of the upregulation of Pim-1 expression from NCMT to OSCC. The pathogenetic role of Pim-1 expression in oral tumourigenesis deserves further investigation.
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收藏
页码：740 / 745
页数：6
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