Fluorescent probes for detecting monoamine oxidase activity and cell imaging

被引：41

作者：

Li, Xuefeng ^{[1
]}

Zhang, Huatang ^{[2
]}

Xie, Yusheng ^{[2
]}

Hu, Yi ^{[3
]}

Sun, Hongyan ^{[2
]}

Zhu, Qing ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Inst Bioengn, Hangzhou 310014, Zhejiang, Peoples R China

[2] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China

[3] Chinese Acad Sci, Inst High Energy Phys,Ctr Multidisciplinary Res, CAS Key Lab Nucl Radiat & Nucl Energy Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 13期

基金：

美国国家科学基金会;

关键词：

LIVING CELLS; FLUOROGENIC PROBES; DESIGN; ASSAYS;

D O I：

10.1039/c3ob42326c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and beta-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 mu g mL(-1) respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells.

引用

页码：2033 / 2036

页数：4

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