Chemical composition and anticholinesterase inhibitory activity of Pavetta graciliflora Wall. ex Ridl. essential oil

被引：19
作者：
Salleh, Wan Mohd Nuzul Hakimi Wan [1 ]
Khamis, Shamsul [2 ]
机构：
[1] Univ Pendidikan Sultan Idris UPSI, Fac Sci & Math, Dept Chem, Tanjong Malim 35900, Perak, Malaysia
[2] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Environm & Nat Sci, Bangi 43600, Selangor, Malaysia
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2020年 / 75卷 / 11-12期
关键词：
anticholinesterase; beta-caryophyllene; essential oil; Pavetta graciliflora; Rubiaceae; BETA-CARYOPHYLLENE; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE; EXTRACT;
D O I：
10.1515/znc-2020-0075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical composition and anticholinesterase activity of the essential oil of Pavetta graciliflora Wall. ex Ridl. (Rubiaceae) was examined for the first time. The essential oil was obtained by hydrodistillation and was fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 20 components were identified in the essential oil, which made up 92.85% of the total oil. The essential oil is composed mainly of beta-caryophyllene (42.52%), caryophyllene oxide (25.33%), beta-pinene (8.67%), and alpha-pinene (6.52%). The essential oil showed weak inhibitory activity against acetylcholinesterase (AChE) (1%: 62.5%) and butyrylcholinesterase (BChE) (1%; 65.4%) assays. Our findings were shown to be very useful for the characterization, pharmaceutical, and therapeutic applications of the essential oil from P. graciliflora.
引用
收藏
页码：467 / 471
页数：5
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