Comparison of Enhanced Photocatalytic Degradation Efficiency and Toxicity Evaluations of CeO2 Nanoparticles Synthesized Through Double-Modulation

被引：6

作者：

Choi, Jang Hyun ^{[1
]}

Hong, Jung-A ^{[2
]}

Son, Ye Rim ^{[3
]}

Wang, Jian ^{[4
,5
]}

Kim, Hyun Sung ^{[3
]}

Lee, Hansol ^{[1
]}

Lee, Hangil ^{[2
]}

机构：

[1] Inha Univ, Coll Nat Sci, Dept Biol Sci, 100 Inha Ro, Incheon 22212, South Korea

[2] Sookmyung Womens Univ, Dept Chem, Seoul 04310, South Korea

[3] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea

[4] Canadian Light Source, 44 Innovat Blvd, Saskatoon, SK S7N 2 V3, Canada

[5] Univ Saskatchewan, 44 Innovat Blvd, Saskatoon, SK S7N 2 V3, Canada

来源：

NANOMATERIALS | 2020年 / 10卷 / 08期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会; 加拿大健康研究院; 新加坡国家研究基金会;

关键词：

modified CeO(2)NPs; oxygen vacancy; photocatalytic degradation; scanning transmission X-ray microscopy; toxicity; cell penetration; CERIUM OXIDE NANOPARTICLES; METAL-OXIDE; OXIDATIVE STRESS; OXYGEN VACANCIES; CYTOTOXICITY; CELL; GENERATION; NANORODS; PATHWAY; ASSAY;

D O I：

10.3390/nano10081543

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrated that Fe/Cr doped and pH-modified CeO(2)nanoparticles (NPs) exhibit enhanced photocatalytic performance as compared to bare CeO(2)NPs, using photocatalytic degradation. To assess the toxicity level of these double-modified CeO(2)NPs on the human skin, they were introduced into HaCaT cells. The results of our conventional cellular toxicity assays (neutral red uptake and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide for assays) indicated that Cr@CeO(x)NPs prompt severe negative effects on the viability of human cells. Moreover, the results obtained by scanning transmission X-ray microscopy and bio-transmission electron microscope analysis showed that most of the NPs were localized outside the nucleus of the cells. Thus, serious genetic toxicity was unlikely. Overall, this study highlights the need to prevent the development of Cr@CeOxNP toxicity. Moreover, further research should aim to improve the photocatalytic properties and activity of these NPs while accounting for their stability issues.

引用

页码：1 / 11

页数：11

共 48 条

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