Hearing loss and microstructural integrity of the brain in a dementia-free older population

被引：25

作者：

Croll, Pauline H. ^{[1
,2
,3
,4
]}

Vernooij, Meike W. ^{[3
,4
]}

Reid, Robert, I ^{[5
]}

Goedegebure, Andre ^{[1
]}

Power, Melinda C. ^{[6
]}

Rigters, Stephanie C. ^{[1
]}

Sharrett, A. Richey ^{[7
]}

de Jong, Robert J. Baatenburg ^{[1
]}

Mosley, Thomas H. ^{[8
]}

de Groot, Marius ^{[3
,4
,9
]}

Lin, Frank R. ^{[2
,7
,10
]}

Deal, Jennifer A. ^{[2
,7
]}

机构：

[1] Erasmus MC, Dept Otorhinolaryngol Head & Neck Surg, Rotterdam, Netherlands

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Cochlear Ctr Hearing & Publ Hlth, 2024 E Monument St Suite 2-700, Baltimore, MD 21205 USA

[3] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[4] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[5] Mayo Clin Fdn, Dept Informat Technol, Rochester, MN USA

[6] George Washington Univ, Dept Epidemiol, Milken Inst, Sch Publ Hlth, Washington, DC USA

[7] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[8] Univ Mississippi, Med Ctr, MIND Ctr, Jackson, MS 39216 USA

[9] Erasmus MC, Dept Med Informat, Rotterdam, Netherlands

[10] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 11期

基金：

美国国家卫生研究院;

关键词：

diffusion imaging; hearing loss; hippocampus; microstructural integrity; temporal lobe; ATHEROSCLEROSIS RISK; DIFFUSION; IMPAIRMENT; MARKERS; IMAGES; VOLUME;

D O I：

10.1002/alz.12151

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: As hearing loss has been identified as an important risk factor for dementia, we aimed to assess the association between hearing loss and microstructural integrity of the brain. Methods: A total of 1086 dementia-free participants (mean age = 75.2 [standard deviation: 4.9], 61.4% female) of the population-based Atherosclerosis Risk in Communities (ARIC) study underwent hearing assessment (2016-2017) and magnetic resonance imaging of the brain (2011-2013). Microstructural integrity was determined with diffusion tensor imaging. Multivariable linear regression was used to investigate associations between hearing loss and microstructural integrity of different brain regions and white matter (WM) tracts. Results: Hearing loss was associated with lower WM microstructural integrity in the temporal lobe, lower gray matter integrity of the hippocampus, and with lower WM microstructural integrity of the limbic tracts and the uncinate fasciculus. Conclusion: Our results demonstrate that hearing loss is indepedently associated with lower microstructural integrity in brain regions that are important for different cognitive processes.

引用

页码：1515 / 1523

页数：9

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