A genomewide association mapping study using ultrasound-scanned information identifies potential genomic regions and candidate genes affecting carcass traits in Nellore cattle

被引：35

作者：

Santana, M. H. A. ^{[1
]}

Ventura, R. V. ^{[1
,2
,3
]}

Utsunomiya, Y. T. ^{[4
]}

Neves, H. H. R. ^{[4
,5
]}

Alexandre, P. A. ^{[1
]}

Oliveira Junior, G. A. ^{[1
]}

Gomes, R. C. ^{[6
]}

Bonin, M. N. ^{[6
]}

Coutinho, L. L. ^{[7
]}

Garcia, J. F. ^{[4
]}

Silva, S. L. ^{[1
]}

Fukumasu, H. ^{[1
]}

Leme, P. R. ^{[1
]}

Ferraz, J. B. S. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Zootecnia Engn Alimentos, BR-13635900 Pirassununga, SP, Brazil

[2] Univ Guelph, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1, Canada

[3] BIO, Guelph, ON, Canada

[4] UNESP, Fac Ciencias Agr & Vet, Jaboticabal, Brazil

[5] GenSys Consultores Associados SC Ltda, Porto Alegre, RS, Brazil

[6] CNPGC EMBRAPA, Empresa Brasileira Pesquisa Agropecuaria, Campo Grande, Brazil

[7] Univ Sao Paulo, Escola Super Agr Luiz Queiroz, Piracicaba, Brazil

来源：

JOURNAL OF ANIMAL BREEDING AND GENETICS | 2015年 / 132卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Bos indicus; candidate genes; fat thickness; genomewide association studies; single nucleotide polymorphisms; ultrasonography; SINGLE NUCLEOTIDE POLYMORPHISMS; WIDE ASSOCIATION; FEED-EFFICIENCY; BEEF-CATTLE; GROWTH; ANGUS; LOCI; EXPRESSION; QUALITY; BREEDS;

D O I：

10.1111/jbg.12167

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The aim of this study was to identify candidate genes and genomic regions associated with ultrasound-derived measurements of the rib-eye area (REA), backfat thickness (BFT) and rumpfat thickness (RFT) in Nellore cattle. Data from 640 Nellore steers and young bulls with genotypes for 290 863 single nucleotide polymorphisms (SNPs) were used for genomewide association mapping. Significant SNP associations were explored to find possible candidate genes related to physiological processes. Several of the significant markers detected were mapped onto functional candidate genes including ARFGAP3, CLSTN2 and DPYD for REA; OSBPL3 and SUDS3 for BFT; and RARRES1 and VEPH1 for RFT. The physiological pathway related to lipid metabolism (CLSTN2, OSBPL3, RARRES1 and VEPH1) was identified. The significant markers within previously reported QTLs reinforce the importance of the genomic regions, and the other loci offer candidate genes that have not been related to carcass traits in previous investigations.

引用

页码：420 / 427

页数：8

共 2 条

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[2] Large-scale integration of meta-QTL and genome-wide association study identifies genomic regions and candidate genes for photosynthetic efficiency traits in bread wheat
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