Susceptibility to type 1 diabetes in the Senegalese population is linked to HLA-DQ and not TAP and LMP genes

被引：12

作者：

Chauffert, M ^{[1
]}

Cisse, A ^{[1
]}

Chevenne, D ^{[1
]}

You, JF ^{[1
]}

Michel, S ^{[1
]}

Trivin, E ^{[1
]}

机构：

[1] UNIV CHEIKH ANTA DIOP,FAC MED & PHARM,LAB PHYS PHARMACEUT,DAKAR,SENEGAL

来源：

DIABETES CARE | 1997年 / 20卷 / 08期

关键词：

D O I：

10.2337/diacare.20.8.1299

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To investigate the frequency of the transporter associated with antigen processing (TAP) and large multifunctional protease (LMP) alleles and their role in the susceptibility to type 1 diabetes, in comparison with the well-known HLA-DQ alleles susceptibility, in Senegalese subjects. RESEARCH DESIGN AND METHODS - Three loci in the TAP/LMP region were analyzed in 92 type 1 diabetic subjects and 117 nondiabetic control subjects by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS - No association was found between the studied polymorphisms of TAP1, TAP2, and LMP2 and type I diabetes in the Senegalese population, in contrast to the HLA-DQA1 and DQB1 genes, which were associated with type 1 diabetes. CONCLUSIONS - Diabetogenic genes in the class II HLA region are located near the DQA1 and DQB1 loci rather than the TAP and LMP loci.

引用

页码：1299 / 1303

页数：5

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