How death shapes life during development

被引：310
作者：
Baehrecke, EH [1 ]
机构：
[1] Univ Maryland, Maryland Biotechnol Inst, Ctr Biosyst Res, College Pk, MD 20742 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 10期
关键词：
D O I：
10.1038/nrm931
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The formation of an adult animal from a fertilized embryo involves the production and death of cells. Surprisingly, many cells are produced during development with an ultimate fate of death, and defects in programmed cell death can result in developmental abnormalities. Recent studies indicate that cells can die by many different mechanisms, and these differences have implications for proper animal development and disorders such as cancer and autoimmunity.
引用
收藏
页码：779 / 787
页数：9
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共 118 条
  • [1] ABRAMS JM, 1993, DEVELOPMENT, V117, P29
  • [2] The Bcl-2 protein family: Arbiters of cell survival
    Adams, JM
    Cory, S
    [J]. SCIENCE, 1998, 281 (5381) : 1322 - 1326
  • [3] Human ICE/CED-3 protease nomenclature
    Alnemri, ES
    Livingston, DJ
    Nicholson, DW
    Salvesen, G
    Thornberry, NA
    Wong, WW
    Yuan, JY
    [J]. CELL, 1996, 87 (02) : 171 - 171
  • [4] Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
    Aravind, L
    Dixit, VM
    Koonin, EV
    [J]. SCIENCE, 2001, 291 (5507) : 1279 - +
  • [5] Steroid regulation of programmed cell death during Drosophila development
    Baehrecke, EH
    [J]. CELL DEATH AND DIFFERENTIATION, 2000, 7 (11) : 1057 - 1062
  • [6] CELL-DEATH AND CONTROL OF CELL-SURVIVAL IN THE OLIGODENDROCYTE LINEAGE
    BARRES, BA
    HART, IK
    COLES, HSR
    BURNE, JF
    VOYYODIC, JT
    RICHARDSON, WD
    RAFF, MC
    [J]. CELL, 1992, 70 (01) : 31 - 46
  • [7] Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling
    Bergmann, A
    Tugentman, M
    Shilo, BZ
    Steller, H
    [J]. DEVELOPMENTAL CELL, 2002, 2 (02) : 159 - 170
  • [8] Bodenstein D, 1965, BIOL DROSOPHILA
  • [9] The Drosophila βFTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone
    Broadus, J
    McCabe, JR
    Endrizzi, B
    Thummel, CS
    Woodard, CT
    [J]. MOLECULAR CELL, 1999, 3 (02) : 143 - 149
  • [10] Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
    Cecconi, F
    Alvarez-Bolado, G
    Meyer, BI
    Roth, KA
    Gruss, P
    [J]. CELL, 1998, 94 (06) : 727 - 737
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