Direct electrochemistry of porcine purple acid phosphatase (uteroferrin)

被引：48
|
作者：
Bernhardt, PV [1 ]
Schenk, G [1 ]
Wilson, GJ [1 ]
机构：
[1] Univ Queensland, Ctr Met Biol, Dept Chem, Brisbane, Qld 4072, Australia
来源：
BIOCHEMISTRY | 2004年 / 43卷 / 32期
关键词：
D O I：
10.1021/bi0490338
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclic voltammetry of the non-heme diiron enzyme porcine purple acid phosphatase (uteroferrin, Uf) has been reported for the first time. Totally reversible one-electron oxidation responses (Fe-III-Fe-II --> Fe-III-Fe-III) are seen both in the absence and in the presence of weak competitive inhibitors phosphate and arsenate, and dissociation constants of these oxoanion complexes formed with uteroferrin in its oxidized state (Uf(o)) have been determined. The effect of pH on the redox potentials has been investigated in the range 3 < pH < 6.5, enabling acid dissociation constants for Uf(o) and its phosphate and arsenate complexes to be calculated.
引用
收藏
页码：10387 / 10392
页数：6
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