Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice

被引：6
作者：
Betts, Matthew J. [1 ,2 ]
Ehrenberg, Alexander J. [3 ]
Haemmerer, Dorothea [1 ,4 ,5 ]
Duezel, Emrah [1 ,2 ,4 ]
机构：
[1] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
[2] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res, Magdeburg, Germany
[3] Univ Calif San Francisco, Weill Inst Neurosci, Memory & Aging Ctr, San Francisco, CA 94143 USA
[4] UCL, Inst Cognit Neurosci, London, England
[5] UCL, Wellcome Trust Ctr Neuroimaging, London, England
来源：
FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷
基金：
欧盟地平线“2020”;
关键词：
locus coeruleus; norepinephrine; hippocampus; tauopathy; learning and memory; neuropathology; ALZHEIMERS-DISEASE; PROGRESSION; DEMENTIA; CERULEUS; BRAINS; MODEL; AGE;
D O I：
10.3389/fnins.2018.00401
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
引用
收藏
页数：3
相关论文
共 21 条
[1]   In vivo MRI assessment of the human locus coeruleus along its rostrocaudal extent in young and older adults [J].
Betts, Matthew J. ;
Cardenas-Blanco, Arturo ;
Kanowski, Martin ;
Jessen, Frank ;
Duezel, Emrah .
NEUROIMAGE, 2017, 163 :150-159
[2]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[3]   Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years [J].
Braak, Heiko ;
Thal, Dietmar R. ;
Ghebremedhin, Estifanos ;
Del Tredici, Kelly .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2011, 70 (11) :960-969
[4]   Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice [J].
Chalermpalanupap, Termpanit ;
Schroeder, Jason P. ;
Rorabaugh, Jacki M. ;
Liles, L. Cameron ;
Lah, James J. ;
Levey, Allan I. ;
Weinshenker, David .
JOURNAL OF NEUROSCIENCE, 2018, 38 (01) :74-92
[5]   Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease [J].
Ehrenberg, A. J. ;
Nguy, A. K. ;
Theofilas, P. ;
Dunlop, S. ;
Suemoto, C. K. ;
Di Lorenzo Alho, A. T. ;
Leite, R. P. ;
Diehl Rodriguez, R. ;
Mejia, M. B. ;
Rueb, U. ;
Farfel, J. M. ;
de Lucena Ferretti-Rebustini, R. E. ;
Nascimento, C. F. ;
Nitrini, R. ;
Pasquallucci, C. A. ;
Jacob-Filho, W. ;
Miller, B. ;
Seeley, W. W. ;
Heinsen, H. ;
Grinberg, L. T. .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2017, 43 (05) :393-408
[6]   Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease [J].
Giannakopoulos, P ;
Herrmann, FR ;
Bussière, T ;
Bouras, C ;
Kövari, E ;
Perl, DP ;
Morrison, JH ;
Gold, G ;
Hof, PR .
NEUROLOGY, 2003, 60 (09) :1495-1500
[7]   Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events [J].
Haemmerer, Dorothea ;
Callaghan, Martina F. ;
Hopkins, Alexandra ;
Kosciessa, Julian ;
Betts, Matthew ;
Cardenas-Blanco, Arturo ;
Kanowski, Martin ;
Weiskopf, Nikolaus ;
Dayan, Peter ;
Dolan, Raymond J. ;
Duezel, Emrah .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (09) :2228-2233
[8]   Locus Ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice [J].
Heneka, MT ;
Ramanathan, M ;
Jacobs, AH ;
Dumitrescu-Ozimek, L ;
Bilkei-Gorzo, A ;
Debeir, T ;
Sastre, M ;
Galldiks, N ;
Zimmer, A ;
Hoehn, M ;
Heiss, WD ;
Klockgether, T ;
Staufenbiel, M .
JOURNAL OF NEUROSCIENCE, 2006, 26 (05) :1343-1354
[9]   The role of norepinephrine in the behavioral and psychological symptoms of dementia [J].
Herrmann, N ;
Lanctôt, KL ;
Khan, LR .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2004, 16 (03) :261-276
[10]   Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits [J].
Jardanhazi-Kurutz, Daniel ;
Kummer, Markus P. ;
Terwel, Dick ;
Vogel, Kim ;
Dyrks, Thomas ;
Thiele, Andrea ;
Heneka, Michael T. .
NEUROCHEMISTRY INTERNATIONAL, 2010, 57 (04) :375-382
123