Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin

被引:146
作者
Govender, Jenelle [1 ]
Loos, Ben [1 ]
Marais, Erna [2 ]
Engelbrecht, Anna-Mart [1 ]
机构
[1] Univ Stellenbosch, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa
[2] Univ Stellenbosch, Fac Med, Dept Med Physiol, ZA-7505 Tygerberg, South Africa
基金
新加坡国家研究基金会;
关键词
cell death and mitochondrial fission; fusion; doxorubicin-induced cardiotoxicity; heart; melatonin; metabolism and ATP production; mitochondria; reactive oxygen species; FATTY-ACID-METABOLISM; OXIDATIVE STRESS; CELL-DEATH; IN-VIVO; PERMEABILITY TRANSITION; CARDIAC MITOCHONDRIA; HYDROGEN-PEROXIDE; INDUCED APOPTOSIS; GENE-EXPRESSION; DNA-DAMAGE;
D O I
10.1111/jpi.12176
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Anthracyclines, such as doxorubicin, are among the most valuable treatments for various cancers, but their clinical use is limited due to detrimental side effects such as cardiotoxicity. Doxorubicin-induced cardiotoxicity is emerging as a critical issue among cancer survivors and is an area of much significance to the field of cardio-oncology. Abnormalities in mitochondrial functions such as defects in the respiratory chain, decreased adenosine triphosphate production, mitochondrial DNA damage, modulation of mitochondrial sirtuin activity and free radical formation have all been suggested as the primary causative factors in the pathogenesis of doxorubicin-induced cardiotoxicity. Melatonin is a potent antioxidant, is nontoxic, and has been shown to influence mitochondrial homeostasis and function. Although a number of studies support the mitochondrial protective role of melatonin, the exact mechanisms by which melatonin confers mitochondrial protection in the context of doxorubicin-induced cardiotoxicity remain to be elucidated. This review focuses on the role of melatonin on doxorubicin-induced bioenergetic failure, free radical generation, and cell death. A further aim is to highlight other mitochondrial parameters such as mitophagy, autophagy, mitochondrial fission and fusion, and mitochondrial sirtuin activity, which lack evidence to support the role of melatonin in the context of cardiotoxicity.
引用
收藏
页码:367 / 380
页数:14
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