Neuroregenerative effects of preinjury FK-506 administration

被引：36
作者：
Snyder, Alison K. [1 ]
Fox, Ida K. [1 ]
Nichols, Chris M. [1 ]
Rickman, Susan R. [1 ]
Hunter, Daniel A. [1 ]
Tung, Thomas H. H. [1 ]
Mackinnon, Susan E. [1 ]
机构：
[1] Washington Univ, Sch Med, Div Plast & Reconstruct Surg, Dept Surg, St Louis, MO 63110 USA
来源：
PLASTIC AND RECONSTRUCTIVE SURGERY | 2006年 / 118卷 / 02期
关键词：
D O I：
10.1097/01.prs.0000227628.43867.5b
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: FK-506 is used in organ transplantation because it promotes neurite outgrowth in vitro and enhances neuroregeneration in peripheral nerve injury transection models. Immunosuppressive mechanisms of FK-506 are well defined, with demonstration of decreased neuroregenerative effects with delayed administration. The purpose of this study was to describe the effects of preinjury administration of FK-506 in rats with tibial nerve transection injury. Methods: Eight inbred male Lewis rats per group in three separate groups underwent tibial nerve transection with primary repair. Group I received placebo, group II received FK-506 treatment at 1 day before surgery, and group III received FK-506 preloading 3 days before surgery. Results: Histologic and histomorphometric results demonstrated the preload FK-506 group had superior results compared with the immediate FK-506 group. Both FK-506 groups were superior to the placebo group. The preload FK-506 demonstrated superior regeneration in mean total nerve fiber counts (p < 0.05), greater percentage neural tissue (p < 0.05), greater mean nerve fiber density (p < 0.05), and lower percentage of debris (p > 0.05). Mean nerve fiber widths were similar in the preload and immediate FK-506 groups but superior to the placebo group. Conclusion: These data suggest that enhancement of FK-506's neuroregenerative effect is enhanced when administered before nerve injury such as when performing elective surgery.
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页码：360 / 367
页数：8
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