Activity-based sensing fluorescent probes for iron in biological systems

被引：81

作者：

Aron, Allegra T. ^{[1
]}

Reeves, Audrey G. ^{[1
]}

Chang, Christopher J. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Cell Biol, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2018年 / 43卷

关键词：

DEPENDENT DRUG-DELIVERY; LABILE IRON; LIVING CELLS; CHELATABLE IRON; METAL-IONS; IN-VIVO; DISPIRO-1,2,4-TRIOXOLANE ANTIMALARIALS; HEME ALKYLATION; REACTIVITY; HEPATOCYTES;

D O I：

10.1016/j.cbpa.2017.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.

引用

页码：113 / 118

页数：6

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