Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

被引：48
作者：
Ozsoy, Saliha [1 ]
Besirli, Asli [2 ]
Abdulrezzak, Ummuhan [3 ]
Basturk, Mustafa [1 ]
机构：
[1] Erciyes Univ, Sch Med, Dept Psychiat, TR-38039 Kayseri, Turkey
[2] Mus State Hosp, Dept Psychiat, Mus, Turkey
[3] Erciyes Univ, Sch Med, Dept Nucl Med, TR-38039 Kayseri, Turkey
来源：
PSYCHIATRY INVESTIGATION | 2014年 / 11卷 / 02期
关键词：
Depression; Ghrelin; Leptin; Treatment; HYPOTHALAMIC 4B CELLS; ANTIDEPRESSANT TREATMENT; CIRCULATING GHRELIN; CHOLESTEROL LEVELS; MAJOR DEPRESSION; MOOD DISORDERS; PLASMA-LEVELS; BODY-WEIGHT; OBESITY; MIRTAZAPINE;
D O I：
10.4306/pi.2014.11.2.167
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective Ghrelin and leptin, appetite-regulating hormones, play a role in mood regulation. Current data about the relation between leptin/ghrelin and depression are still controversial. This study aimed to investigate serum leptin and ghrelin levels in patients with depression and the effects of treatment on these levels. Methods Serum ghrelin and leptin levels were measured before and after treatment with antidepressant drugs and/or electroconvulsive therapy in 28 patients with depression and once in 21 healthy controls. Results Serum ghrelin levels of the patients were high in the pre-treatment. After the treatment, ghrelin levels were not different from those of the controls. We found no difference in serum levels of leptin between the patients and controls and no change with treatment. body mass index of the patients increased after the treatment especially in the drug-treated group. Conclusion The present study found increased serum ghrelin levels in depressive patients and normalization with improving of depression but no alteration in leptin levels.
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页码：167 / 172
页数：6
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