Discovery of a practical direct O2-coupled Wacker oxidation with Pd[(-)-sparteine]Cl2

被引：89

作者：

Cornell, Candace N. ^{[1
]}

Sigman, Matthew S. ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 18期

关键词：

D O I：

10.1021/ol061662h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The discovery of a direct O-2-coupled Wacker oxidation with use of balloon pressure of O-2 and low catalyst loading is described. Use of (-)-sparteine as a ligand on Pd prevents olefin isomerization and leads to selective formation of methyl ketones from terminal olefins in good yields. Oxidation of enantiomerically enriched substrates is reported with no observed racemization.

引用

页码：4117 / 4120

页数：4

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