GeneWise and genomewise

被引：2046

作者：

Birney, E

Clamp, M

Durbin, R

机构：

[1] European Bioinformat Inst, Cambridge CB10 1SA, England

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

来源：

GENOME RESEARCH | 2004年 / 14卷 / 05期

关键词：

D O I：

10.1101/gr.1865504

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.

引用

页码：988 / 995

页数：8

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