Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer

被引：54
作者：
Pan, Yunbao [1 ,2 ,3 ]
Yang, Huiling [2 ]
Claret, Francois X. [1 ,4 ,5 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510275, Guangdong, Peoples R China
[4] Univ Texas Houston, Grad Sch Biomed Sci, Expt Therapeut Acad Program, Houston, TX USA
[5] Univ Texas Houston, Grad Sch Biomed Sci, Canc Biol Program, Houston, TX USA
来源：
CANCER BIOLOGY & THERAPY | 2014年 / 15卷 / 03期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
genomic instability; therapeutic approach; DNA damage; tumorigenesis; Jab1/CSN5; DOMAIN-BINDING PROTEIN-1; COP9; SIGNALOSOME; JAB1; EXPRESSION; MOLECULAR-BASIS; FANCONI-ANEMIA; BREAST; SUSCEPTIBILITY; ACTIVATION; COMPLEX; RECOMBINATION;
D O I：
10.4161/cbt.27823
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.
引用
收藏
页码：256 / 262
页数：7
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