Marine Organisms with Anti-Diabetes Properties

被引:77
作者
Lauritano, Chiara [1 ]
Ianora, Adrianna [1 ]
机构
[1] Stn Zool Anton Dohrn, Dept Integrat Marine Ecol, I-80121 Naples, Italy
关键词
marine organisms; metabolic disorder; diabetes; microalgae; marine biotechnology; drug discovery; ALGA ECKLONIA-STOLONIFERA; POTENT ALPHA-GLUCOSIDASE; TYROSINE-PHOSPHATASE; 1B; BIOACTIVE COMPOUNDS; INHIBITORY-ACTIVITY; FATTY-ACIDS; IN-VITRO; FISH-OIL; SPONGE; INSULIN;
D O I
10.3390/md14120220
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Diabetes is a chronic degenerative metabolic disease with high morbidity and mortality rates caused by its complications. In recent years, there has been a growing interest in looking for new bioactive compounds to treat this disease, including metabolites of marine origin. Several aquatic organisms have been screened to evaluate their possible anti-diabetes activities, such as bacteria, microalgae, macroalgae, seagrasses, sponges, corals, sea anemones, fish, salmon skin, a shark fusion protein as well as fish and shellfish wastes. Both in vitro and in vivo screenings have been used to test anti-hyperglycemic and anti-diabetic activities of marine organisms. This review summarizes recent discoveries in anti-diabetes properties of several marine organisms as well as marine wastes, existing patents and possible future research directions in this field.
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页数:14
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