Angiotensin I converting enzyme gene cosegregates with blood pressure and heart weight in F2 progeny derived from spontaneously hypertensive and normotensive Wistar-Kyoto rats

被引:23
作者
Zhang, L [1 ]
Summers, KM [1 ]
West, MJ [1 ]
机构
[1] UNIV QUEENSLAND, PRINCE CHARLES HOSP,DEPT MED, BRISBANE, QLD 4032, AUSTRALIA
关键词
genetic hypertension; cardiac hypertrophy; ACE gene; SHR;
D O I
10.3109/10641969609081779
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present investigation examines the association of angiotesin I converting enzyme (ACE) genotypes with blood pressure and heart weight in an F2 population of rats derived from a cross between spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. ACE genotype of rats in the F2 population was determined using a microsatellite polymorphism. Our investigation revealed that cardiac mass was not correlated with blood pressure at 12 weeks of age within the SHR, WKY, F1 or F2, groups of rats. In male rats, ACE genotype accounted for approximately 20% of the difference in mean blood pressure between SHR and WKY fats. There was no effect in females. It was also responsible for 21%-29% of the difference in heart weight both in female and male animals. The allele derived from the SHR parent appeared recessive to the allele from WKY parent for both heart weight and blood pressure, These results suggest that a gene in the region of the ACE locus is one of the genetic factors influencing blood pressure and heart weight in SHR.
引用
收藏
页码:753 / 771
页数:19
相关论文
共 39 条
[1]   LEFT-VENTRICULAR STRUCTURE AND DETERMINANTS IN NORMOTENSIVE OFFSPRING OF ESSENTIAL HYPERTENSIVE PARENTS [J].
ALLEMANN, Y ;
AESCHBACHER, B ;
ZWYSSIG, P ;
FERRARI, P ;
HOPF, M ;
SHAW, S ;
GURTNER, HP ;
WEIDMANN, P .
JOURNAL OF HYPERTENSION, 1992, 10 (10) :1257-1264
[2]   ANGIOTENSIN-II INDUCES CARDIOVASCULAR HYPERTROPHY IN PERINDOPRIL-TREATED RATS [J].
BLACK, MJ ;
BERTRAM, JF ;
CAMPBELL, JH ;
CAMPBELL, GR .
JOURNAL OF HYPERTENSION, 1995, 13 (06) :683-692
[3]  
CICILA GT, 1994, J HYPERTENS, V12, P643
[4]   MYOCARDIAL HYPERTROPHY AND VENTRICULAR PERFORMANCE IN ABSENCE OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS [J].
CUTILLETTA, AF ;
BENJAMIN, M ;
CULPEPPER, WS ;
OPARIL, S .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1978, 10 (08) :689-703
[5]   EVALUATION OF RIGHT AND LEFT-VENTRICULAR SIZE IN SHR-WISTAR HYBRIDS [J].
DEGENDE, AOG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (03) :H587-H591
[6]   COSEGREGATION OF BLOOD-PRESSURE WITH ANGIOTENSIN CONVERTING ENZYME AND ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR GENES USING DAHL SALT-SENSITIVE RATS [J].
DENG, YL ;
RAPP, JP .
NATURE GENETICS, 1992, 1 (04) :267-272
[7]  
DOBESOVA Z, 1991, PHYSIOL RES, V40, P373
[8]  
FISHER CR, 1993, BIOGEOCHEMISTRY OF GLOBAL CHANGE, P606
[9]  
FROHLICH ED, 1981, HEART HYPERTENSION, P425
[10]   SEX INFLUENCE ON RENAL ALPHA(2)-ADRENERGIC RECEPTOR DENSITY IN THE SPONTANEOUSLY HYPERTENSIVE RAT [J].
GONG, GD ;
DOBIN, A ;
MCARDLE, S ;
SUN, L ;
JOHNSON, ML ;
PETTINGER, WA .
HYPERTENSION, 1994, 23 (05) :607-612