Studies towards a total synthesis of the antiprogestine onapristone

被引：10

作者：

Enev, VS ^{[1
]}

Petrov, OS ^{[1
]}

Neh, H ^{[1
]}

Nickisch, K ^{[1
]}

机构：

[1] SCHERING AG,PROC RES,D-13342 BERLIN,GERMANY

来源：

TETRAHEDRON | 1997年 / 53卷 / 40期

关键词：

D O I：

10.1016/S0040-4020(97)00934-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from the readily available Eder-Hajosh ketone 2 a stereoselective method for synthesis of arylated hydrindenone 14 was developed. One pot Li/NH3 reduction and trapping of the generated enolate with activated Michael acceptor gave a properly substituted BCD-ring precursor 22. Attempted B ring closure with the model compound 22 failed under various conditions. (C) 1997 Elsevier Science Ltd.

引用

页码：13709 / 13718

页数：10

共 16 条

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