Two Decades of New Concepts in Nitric Oxide Signaling: From the Discovery of a Gas Messenger to the Mediation of Nonenzymatic Posttranslational Modifications

被引：37
作者：
Martinez-Ruiz, Antonio [2 ]
Lamas, Santiago [1 ]
机构：
[1] CSIC, Ctr Invest Biol, Lab Mixto CSIC FRIAT Fisiopatol Vasc & Renal, E-28040 Madrid, Spain
[2] Hosp La Princesa, Serv Inmunol, E-28006 Madrid, Spain
来源：
IUBMB LIFE | 2009年 / 61卷 / 02期
关键词：
nitric oxide; signaling; posttranslational modifications; cGMP; S-nitrosylation; S-glutathionylation; tyrosine nitration; MANGANESE SUPEROXIDE-DISMUTASE; PROTEIN S-NITROSYLATION; MITOCHONDRIAL RESPIRATORY-CHAIN; ENDOTHELIAL-CELLS; REACTIVE OXYGEN; NUCLEAR TRANSLOCATION; MOLECULAR-CLONING; GENE-EXPRESSION; SMOOTH-MUSCLE; PEROXYNITRITE;
D O I：
10.1002/iub.144
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
For the past 20 years, nitric oxide (NO) has established itself as a gaseous free radical with crucial and unpredicted roles in a wide spectrum of biological functions and organisms. We present here a case whereby NO-mediated signaling can he broadly classified into classical (cGMP-mediated) and nonclassical, the latter mainly alluding to posttranslational modifications related to NO and its interaction with reactive groups in proteins. (c) 2008 IUBMB
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页码：91 / 98
页数：8
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