A Switchable [2]Rotaxane Asymmetric Organocatalyst That Utilizes an Acyclic Chiral Secondary Amine

被引：171
作者：
Blanco, Victor [1 ]
Leigh, David A. [1 ]
Marcos, Vanesa [1 ]
Morales-Serna, Jose A. [1 ]
Nussbaumer, Alina L. [1 ]
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 13期
基金：
瑞士国家科学基金会; 英国工程与自然科学研究理事会;
关键词：
ALPHA; BETA-UNSATURATED ALDEHYDES; MICHAEL ADDITION; CATALYSIS; ROTAXANE; LIGHT; AMINOCATALYSIS; NANOSWITCH; 3-STATION; STATION; ADVENT;
D O I：
10.1021/ja501561c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A rotaxane-based switchable asymmetric organocatalyst has been synthesized in which the change of the position of the macrocycle reveals or conceals an acyclic, yet still highly effective, chiral organocatalytic group. This allows control over both the rate and stereochemical outcome of a catalyzed asymmetric Michael addition.
引用
收藏
页码：4905 / 4908
页数：4
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