Luminal Conversion and Immunoregulation by Probiotics

被引：19

作者：

Ganesh, Bhanu Priya ^{[1
,2
]}

Versalovic, James ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA

来源：

FRONTIERS IN PHARMACOLOGY | 2015年 / 6卷

基金：

美国国家卫生研究院;

关键词：

probiotics; metabolites; commensal bacteria; immunomodulation; diet; dietary compounds; microbiome; COLON-CANCER CELLS; ESCHERICHIA-COLI; GUT MICROBIOTA; LACTOBACILLUS-REUTERI; COMMENSAL BACTERIA; IN-VITRO; INTESTINAL MICROBIOTA; DENDRITIC CELLS; CROHNS-DISEASE; METABOLISM;

D O I：

10.3389/fphar.2015.00269

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Beneficial microbes are responsible for the synthesis of nutrients and metabolites that are likely important for the maintenance of mammalian health. Many nutrients and metabolites derived from the gut microbiota by luminal conversion have been implicated in the development, homeostasis and function of innate and adaptive immunity. These factors clearly suggest that intestinal microbiota may influence host immunity via microbial metabolite dependent mechanisms. We describe how intestinal microbes including probiotics generate microbial metabolites that modulate mucosal and systemic immunity.

引用

页数：9

共 108 条

[1]

[Anonymous], CURR TOP MICROBIOL I

[2] Probiotic abilities of riboflavin-overproducing Lactobacillus strains: a novel promising application of probiotics [J].

Arena, Mattia P. ;

Russo, Pasquale ;

Capozzi, Vittorio ;

Lopez, Paloma ;

Fiocco, Daniela ;

Spano, Giuseppe .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 98 (17) :7569-7581

[3]

Astbury SM, 2012, CURR DRUG METAB, V13, P815

[4] Inhibition of Cronobacter sakazakii by Heat Labile Bacteriocins Produced by Probiotic LAB Isolated from Healthy Infants [J].

Awaisheh, Saddam S. ;

Al-Nabulsi, Anas A. ;

Osaili, Tareq M. ;

Ibrahim, Salam ;

Holley, Richard .

JOURNAL OF FOOD SCIENCE, 2013, 78 (09) :M1416-M1420

[5] The role of Paneth cells and their antimicrobial peptides in innate host defense [J].

Ayabe, T ;

Ashida, T ;

Kohgo, Y ;

Kono, T .

TRENDS IN MICROBIOLOGY, 2004, 12 (08) :394-398

[6] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[7] Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum [J].

Baumgart, Martin ;

Dogan, Belgin ;

Rishniw, Mark ;

Weitzman, Gil ;

Bosworth, Brian ;

Yantiss, Rhonda ;

Orsi, Renato H. ;

Wiedmann, Martin ;

McDonough, Patrick ;

Kim, Sung Guk ;

Berg, Douglas ;

Schukken, Ynte ;

Scherl, Ellen ;

Simpson, Kenneth W. .

ISME JOURNAL, 2007, 1 (05) :403-418

[8] Human intestinal microbiota Characterization of a simplified and stable gnotobiotic rat model [J].

Becker, Natalie ;

Kunath, Julia ;

Loh, Gunnar ;

Blaut, Michael .

GUT MICROBES, 2011, 2 (01) :25-33

[9] Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation [J].

Berkes, J ;

Viswanathan, VK ;

Savkovic, SD ;

Hecht, G .

GUT, 2003, 52 (03) :439-451

[10] Serotonin synthesis, release and reuptake in terminals: a mathematical model [J].

Best, Janet ;

Nijhout, H. Frederik ;

Reed, Michael .

THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2010, 7

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