Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

被引：2

作者：

Khan, Farheen Badrealam ^{[1
]}

Uddin, Shahab ^{[2
,3
]}

Elderdery, Abozer Y. ^{[4
]}

Goh, Khang Wen ^{[5
]}

Ming, Long Chiau ^{[6
,7
]}

Ardianto, Chrismawan ^{[7
]}

Palakot, Abdul Rasheed ^{[1
]}

Anwar, Irfa ^{[1
]}

Khan, Mohsina ^{[8
]}

Owais, Mohammad ^{[9
]}

Huang, Chih-Yang ^{[10
,11
,12
,13
,14
]}

Daddam, Jayasimha Rayalu ^{[15
]}

Khan, Meraj Alam ^{[16
]}

Shoaib, Shoaib ^{[17
]}

Khursheed, Md ^{[18
]}

Reshadat, Sara ^{[19
]}

Kashani, Hamid Reza Khayat ^{[20
]}

Mirza, Sameer ^{[21
]}

Khaleel, Abbas A. ^{[21
]}

Ayoub, Mohammed Akli ^{[1
,22
,23
]}

机构：

[1] United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain 15551, U Arab Emirates

[2] Hamad Med Corp, Translat Res Inst, Acad Hlth Syst, Doha 3050, Qatar

[3] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, Doha 3050, Qatar

[4] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Sakaka 72388, Saudi Arabia

[5] INTI Int Univ, Fac Data Sci & Informat Technol, Nilai 78100, Negeri Sembilan, Malaysia

[6] Univ Brunei Darussalam, PAPRSB Inst Hlth Sci, BE-1410 Gadong, Brunei

[7] Univ Airlangga, Fac Pharm, Dept Pharm Practice, Surabaya 60115, Indonesia

[8] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[9] Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Aligarh 202002, Uttar Pradesh, India

[10] Asia Univ, Dept Biotechnol, Taichung 404, Taiwan

[11] China Med Univ, Grad Inst Biomed Sci, Taichung 404, Taiwan

[12] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Cardiovasc & Mitochondrial Related Dis Res Ctr, Hualien 970, Taiwan

[13] Tzu Chi Univ Sci & Technol, Buddhist Tzu Chi Med Fdn, Ctr Gen Educ, Hualien 970, Taiwan

[14] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[15] Agr Res Org, Inst Anim Sci, Dept Ruminant Sci, Volcani Ctr, IL-7505101 Rishon Leziyyon, Israel

[16] Hosp Sick Children & DigiBi Inc, Peter Gilgan Ctr Res & Learning, Program Translat Med, Toronto, ON M5 1X8, Canada

[17] Aligarh Muslim Univ, Jawaharlal Nehru Med Coll, Fac Med, Dept Biochem, Aligarh 202002, Uttar Pradesh, India

[18] Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dubai 505055, U Arab Emirates

[19] Semnan Univ Med Sci, Dept Internal Med, Semnan 3513119111, Iran

[20] Imam Hossein Hosp, Madani St, Tehran 1617763141, Iran

[21] United Arab Emirates Univ, Dept Chem, Al Ain 15551, U Arab Emirates

[22] United Arab Emirates Univ, Zayed Ctr Hlth Sci, Al Ain 15551, U Arab Emirates

[23] Khalifa Univ, Coll Arts & Sci, Dept Biol, Abu Dhabi 127788, U Arab Emirates

来源：

CELLS | 2022年 / 11卷 / 22期

关键词：

cardiovascular disease; exosomes; ncRNA; miRNA; lncRNA; circRNA; LONG NONCODING RNAS; EXTRACELLULAR VESICLES; CARDIAC-HYPERTROPHY; ISCHEMIC-MYOCARDIUM; HEART-FAILURE; BREAST-CANCER; IN-VITRO; MICRORNA; DELIVERY; APOPTOSIS;

D O I：

10.3390/cells11223664

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

引用

页数：19

共 143 条

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