Folding DNA into Twisted and Curved Nanoscale Shapes

被引：1035
作者：
Dietz, Hendrik [1 ,2 ]
Douglas, Shawn M. [1 ,2 ,3 ]
Shih, William M. [1 ,2 ,3 ]
机构：
[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
[2] Harvard Univ, Dept Biol Chem & Mol Pharmacol, Sch Med, Boston, MA 02115 USA
[3] Harvard Univ, Wyss Inst Biologically Inspired Engn, Cambridge, MA 02138 USA
来源：
SCIENCE | 2009年 / 325卷 / 5941期
关键词：
DOUBLE-CROSSOVER MOLECULES; CONDUCTIVE NANOWIRES; NANOTUBES; NANOSTRUCTURES; OCTAHEDRON; DESIGN;
D O I：
10.1126/science.1174251
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We demonstrate the ability to engineer complex shapes that twist and curve at the nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to form a custom-shaped bundle of tightly cross-linked double helices, arrayed in parallel to their helical axes. Targeted insertions and deletions of base pairs cause the DNA bundles to develop twist of either handedness or to curve. The degree of curvature could be quantitatively controlled, and a radius of curvature as tight as 6 nanometers was achieved. We also combined multiple curved elements to build several different types of intricate nanostructures, such as a wireframe beach ball or square-toothed gears.
引用
收藏
页码：725 / 730
页数：6
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