Non-coding RNAs in cardiomyocyte proliferation and cardiac regeneration: Dissecting their therapeutic values

被引：12

作者：

Dong, Xiaoxuan ^{[1
]}

Dong, Xiuyun ^{[2
]}

Gao, Feng ^{[1
]}

Liu, Ning ^{[1
]}

Liang, Tian ^{[1
]}

Zhang, Feng ^{[1
]}

Fu, Xuyang ^{[1
]}

Pu, Linbin ^{[1
]}

Chen, Jinghai ^{[1
]}

机构：

[1] Zhejiang Univ, Prov Key Lab Cardiovasc Res, Dept Cardiol, Affiliated Hosp 2,Inst Translat Med,Sch Med, Hangzhou, Peoples R China

[2] Shanxi Cardiovasc Hosp, Dept Cardiol, Taiyuan, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021年 / 25卷 / 05期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

cardiomyocyte proliferation; gene therapy; non-coding RNAs; MYOCARDIAL-INFARCTION; HEART REGENERATION; PROMOTES PROLIFERATION; GENE-EXPRESSION; CELL-CYCLE; MICRORNA; APOPTOSIS; REPAIR; GROWTH; MICE;

D O I：

10.1111/jcmm.16300

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiovascular diseases are associated with high incidence and mortality, contribute to disability and place a heavy economic burden on countries worldwide. Stimulating endogenous cardiomyocyte proliferation and regeneration has been considering as a key to repair the injured heart caused by ischaemia. Emerging evidence has proved that non-coding RNAs participate in cardiac proliferation and regeneration. In this review, we focus on the observation and mechanism that microRNAs (or miRNAs), long non-coding RNAs (or lncRNAs) and circular RNA (or circRNAs) regulate cardiomyocyte proliferation and regeneration to repair a damaged heart. Furthermore, we highlight the potential therapeutic role of some non-coding RNAs used in stimulating CMs proliferation. Finally, perspective on the development of non-coding RNAs therapy in cardiac regeneration is presented.

引用

页码：2315 / 2332

页数：18

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