Efficient and Expeditious Synthesis of Di- and Trisubstituted Thiazoles in PEG Under Catalyst-Free Conditions

被引：47

作者：

Zhu, Dongjian ^{[1
]}

Chen, Jiuxi ^{[1
]}

Xiao, Huilong ^{[1
]}

Liu, Miaochang ^{[1
]}

Ding, Jinchang ^{[1
]}

Wu, Huayue ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 335027, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 16期

关键词：

-Haloketone; PEG-400; thiazoles; thioamides; thioureas; SOLVENT-FREE CONDITIONS; FUNCTIONALIZED THIAZOLES; AMMONIUM THIOCYANATE; ETHYL BROMOPYRUVATE; PROMOTED SYNTHESIS; PHASE SYNTHESIS; ACID-CHLORIDES; IONIC LIQUIDS; 2-AMINOTHIAZOLES; AMINOTHIAZOLES;

D O I：

10.1080/00397910802691874

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and expeditious catalyst-free protocol was developed for the construction of di- and trisubstituted thiazoles from -haloketones and thioureas/thioamides in PEG. The reaction was carried out at ambient temperature, and the products were obtained in excellent isolated yields (91-98%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.

引用

页码：2895 / 2906

页数：12

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