A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides

被引：53

作者：

Ma, Michelle T. ^{[1
,2
]}

Karas, John A. ^{[2
]}

White, Jonathan M. ^{[1
,2
]}

Scanlon, Denis ^{[2
]}

Donnelly, Paul S. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 22期

关键词：

METAL; RADIONUCLIDES; COORDINATION; RADIOTHERAPY; COMPLEXES; DOSIMETRY; MEDICINE; SUBTYPES; SARAR;

D O I：

10.1039/b903426a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new sarcophagine cage amine ligand with a pendent carboxylate functional group has been synthesised; the ligand has been conjugated to tumour targeting peptides ([Tyr(3)]-octreotate and [Lys(3)]-bombesin) and the conjugates radiolabelled with copper-64.

引用

页码：3237 / 3239

页数：3

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