Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear

被引：67

作者：

Peng, Xing-Rong ^{[1
,2
]}

Liu, Jie-Qing ^{[1
]}

Wang, Cui-Fang ^{[1
]}

Li, Xu-Yang ^{[1
,2
]}

Shu, Yi ^{[1
]}

Zhou, Lin ^{[1
]}

Qiu, Ming-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 04期

关键词：

SCLEROTIA;

D O I：

10.1021/np400323u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D-F (3-5) and ganodercochlearins A-C (6-8), together with five known triterpenoids (9-13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities.

引用

页码：737 / 743

页数：7

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