A Frequency Analysis on Calcium T-type Signaling in the Nervous System

被引：0
作者：
Khodaei, Alireza [1 ]
Vakilzadian, Hamid [2 ]
Pierobon, Massimiliano [1 ]
机构：
[1] Univ Nebraska, Comp Sci & Engn, Lincoln, NE 68588 USA
[2] Univ Nebraska, Elect & Comp Engn, Lincoln, NE 68588 USA
来源：
2017 IEEE INTERNATIONAL CONFERENCE ON ELECTRO INFORMATION TECHNOLOGY (EIT) | 2017年
关键词：
Frequency Analysis; Power Spectral Density; Neurons; Calcium Signaling; Calcium T-type Channels; Calcium; Markov Process; Calcium Monte Carlo Simulation; CHANNELS;
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.
引用
收藏
页码：640 / 644
页数：5
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