A Frequency Analysis on Calcium T-type Signaling in the Nervous System

We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.