Synthesis, characterization, DNA interaction, antioxidant and anticancer activity of new ruthenium(II) complexes of thiosemicarbazone/semicarbazone bearing 9,10-phenanthrenequinone

被引：59

作者：

Anitha, Panneerselvam ^{[1
]}

Chitrapriya, Nataraj ^{[2
]}

Jang, Yoon Jung ^{[2
]}

Viswanathamurthi, Periasamy ^{[1
]}

机构：

[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India

[2] Yeungnam Univ, Dept Chem, Kyongsan 712749, Gyeong Buk, South Korea

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2013年 / 129卷

关键词：

Ruthenium(II) complexes; DNA binding; DNA cleavage; Antioxidant; Anticancer activity; METAL-COMPLEXES; IN-VITRO; NAPHTHAQUINONE THIOSEMICARBAZONE; SPECTRAL PROPERTIES; CATALYTIC-ACTIVITY; CRYSTAL-STRUCTURE; ETHIDIUM-BROMIDE; BINDING; INTERCALATION; SPECTROSCOPY;

D O I：

10.1016/j.jphotobiol.2013.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of octahedral ruthenium(II) complexes supported by tridentate ligands derived from phenanthrenequinone and derivatives of thiosemicarbazide/semicarbazide and other co-ligands have been synthesized and characterized. DNA binding experiments indicated that ruthenium(II) complexes can interact with DNA through non-intercalation and the apparent binding constant value (K-b) of [RuCl(CO)(PPh3)(L-3)] (3) at room temperature was calculated to be 2.27 x 10(3) M-1. The DNA cleavage studies showed that the complexes have better cleavage of pBR 322 DNA. Antioxidative activity proved that the complexes have significant radical scavenging activity against free radicals. Cytotoxic activities showed that the ruthenium(II) complexes exhibited more effective cytotoxic activity against selected cancer cells. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：17 / 26

页数：10

共 76 条

[1] Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity [J].

Afrasiabi, Z ;

Sinn, E ;

Lin, WS ;

Ma, YF ;

Campana, C ;

Padhye, S .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2005, 99 (07) :1526-1531

[2] Appended 1,2-naphthoquinones as anticancer agents 1: synthesis, structural, spectral and antitumor activities of ortho-naphthaquinone thiosemicarbazone and its transition metal complexes [J].

Afrasiabi, Z ;

Sinn, E ;

Chen, JN ;

Ma, YF ;

Rheingold, AL ;

Zakharov, LN ;

Rath, N ;

Padhye, S .

INORGANICA CHIMICA ACTA, 2004, 357 (01) :271-278

[3] Transition metal complexes of phenanthrenequinone thiosemicarbazone as potential anticancer agents: synthesis, structure, spectroscopy, electrochemistry and in vitro anticancer activity against human breast cancer cell-line, T47D [J].

Afrasiabi, Z ;

Sinn, E ;

Padhye, S ;

Dutta, S ;

Padhye, S ;

Newton, C ;

Anson, CE ;

Powell, AK .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 95 (04) :306-314

[4]

Ahmed N., 1974, INORG SYNTH, V15, P45

[5]

Allardyce CS, 2001, PLATIN MET REV, V45, P62

[6] Classical and non-classical ruthenium-based anticancer drugs: Towards targeted chemotherapy [J].

Ang, Wee Han ;

Dyson, Paul J. .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2006, (20) :4003-4018

[7] Cu(II) complexes with heterocyclic substituted thiosemicarbazones: The case of 5-formyluracil. Synthesis, characterization, X-ray structures, DNA interaction studies, and biological activity [J].

Baldini, M ;

Belicchi-Ferrari, M ;

Bisceglie, F ;

Pelosi, G ;

Pinelli, S ;

Tarasconi, P .

INORGANIC CHEMISTRY, 2003, 42 (06) :2049-2055

[8] Mixed-Ligand Copper(II) Maltolate Complexes: Synthesis, Characterization, DNA Binding and Cleavage, and Cytotoxicity [J].

Barve, Archika ;

Kumbhar, Avinash ;

Bhat, Menakshi ;

Joshi, Bimba ;

Butcher, Ray ;

Sonawane, Uddhavesh ;

Joshi, Rajendra .

INORGANIC CHEMISTRY, 2009, 48 (19) :9120-9132

[9] OXIDANTS AND ANTIOXIDANTS - STATE-OF-THE-ART [J].

BAST, A ;

HAENEN, GRMM ;

DOELMAN, CJA .

AMERICAN JOURNAL OF MEDICINE, 1991, 91 :S2-S13

[10]

Beckman K.B., 1998, PHYSIOL REV, V78, P447

← 1 2 3 4 5 6 7 8 →