Streptococcal superantigens: categorization and clinical associations

被引：91
作者：
Commons, Robert J. [1 ,2 ]
Smeesters, Pierre R. [2 ,3 ]
Proft, Thomas [4 ]
Fraser, John D. [4 ]
Robins-Browne, Roy [2 ,5 ]
Curtis, Nigel [1 ,2 ,6 ]
机构：
[1] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia
[2] Murdoch Childrens Res Inst, Parkville, Vic, Australia
[3] Univ Libre Bruxelles, Fac Sci, Inst Biol & Med Mol, Lab Genet & Physiol Bacterienne, Gosselies, Belgium
[4] Univ Auckland, Fac Med & Hlth Sci, Dept Mol Med & Pathol, Auckland 1, New Zealand
[5] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
[6] Royal Childrens Hosp Melbourne, Infect Dis Unit, Parkville, Vic, Australia
来源：
TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 01期
关键词：
streptococcus; toxin; nomenclature; toxic shock; invasive disease; INVASIVE GROUP-A; ACUTE RHEUMATIC-FEVER; HUMAN T-CELLS; PERIPHERAL-BLOOD LYMPHOCYTES; POLYMERASE-CHAIN-REACTION; EQUI SUBSP ZOOEPIDEMICUS; PYROGENIC EXOTOXIN-A; SHOCK-LIKE SYNDROME; HEART-DISEASE; MOLECULAR CHARACTERIZATION;
D O I：
10.1016/j.molmed.2013.10.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Superantigens are key virulence factors in the immunopathogenesis of invasive disease caused by group A streptococcus. These protein exotoxins have also been associated with severe group C and group G streptococcal infections. A number of novel streptococcal super-antigens have recently been described with some resulting confusion in their classification. In addition to clarifying the nomenclature of streptococcal superantigens and proposing guidelines for their categorization, this review summarizes the evidence supporting their involvement in various clinical diseases including acute rheumatic fever.
引用
收藏
页码：48 / 62
页数：15
相关论文
共 134 条
[11]   Characterization and immunogenicity of pyrogenic mitogens SePE-H and SePE-I of Streptococcus equi [J].
Artiushin, SC ;
Timoney, JF ;
Sheoran, AS ;
Muthupalani, SK .
MICROBIAL PATHOGENESIS, 2002, 32 (02) :71-85
[12]   Detection of circulating superantigens in an intensive care unit population [J].
Azuma, K ;
Koike, K ;
Kobayashi, T ;
Mochizuki, T ;
Mashiko, K ;
Yamamoto, Y .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2004, 8 (05) :292-298
[13]  
Basma H, 1999, INFECT IMMUN, V67, P1871
[14]   ASSOCIATION OF EXOTOXIN-PRODUCING GROUP-A STREPTOCOCCI AND SEVERE DISEASE IN CHILDREN [J].
BELANI, K ;
SCHLIEVERT, PM ;
KAPLAN, EL ;
FERRIERI, P .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1991, 10 (05) :351-354
[15]   Genome sequence of a serotype M3 strain of group A Streptococcus:: Phage-encoded toxins, the high-virulence phenotype, and clone emergence [J].
Beres, SB ;
Sylva, GL ;
Barbian, KD ;
Lei, BF ;
Hoff, JS ;
Mammarella, ND ;
Liu, MY ;
Smoot, JC ;
Porcella, SF ;
Parkins, LD ;
Campbell, DS ;
Smith, TM ;
McCormick, JK ;
Leung, DYM ;
Schlievert, PM ;
Musser, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10078-10083
[16]  
Bhatnagar A, 1999, CLIN EXP IMMUNOL, V116, P100
[17]   Disease burden due to Streptococcus dysgalactiae subsp equisimilis (group G and C streptococcus) is higher than that due to Streptococcus pyogenes among Mumbai school children [J].
Bramhachari, Pallaval V. ;
Kaul, Santosh Y. ;
McMillan, David J. ;
Shaila, Melkote S. ;
Karmarkar, Mohan G. ;
Sriprakash, Kadaba S. .
JOURNAL OF MEDICAL MICROBIOLOGY, 2010, 59 (02) :220-223
[18]   Lack of mitogenic activity of speG- and speGdys-positive Streptococcus dysgalactiae subspecies equisimilis isolates from patients with invasive infections [J].
Brandt, CM ;
Schweizer, KG ;
Holland, R ;
Lütticken, R ;
Freyaldenhoven, BS .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2005, 295 (08) :539-546
[19]  
BRAUN MA, 1993, J IMMUNOL, V150, P2457
[20]   Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report [J].
Brogan, Robert J. ;
Eleftheriou, Despina ;
Gnanapragasam, James ;
Klein, Nigel J. ;
Brogan, Paul A. .
PEDIATRIC RHEUMATOLOGY, 2009, 7
12345678910