Streptococcal superantigens: categorization and clinical associations

被引：91

作者：

Commons, Robert J. ^{[1
,2
]}

Smeesters, Pierre R. ^{[2
,3
]}

Proft, Thomas ^{[4
]}

Fraser, John D. ^{[4
]}

Robins-Browne, Roy ^{[2
,5
]}

Curtis, Nigel ^{[1
,2
,6
]}

机构：

[1] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[2] Murdoch Childrens Res Inst, Parkville, Vic, Australia

[3] Univ Libre Bruxelles, Fac Sci, Inst Biol & Med Mol, Lab Genet & Physiol Bacterienne, Gosselies, Belgium

[4] Univ Auckland, Fac Med & Hlth Sci, Dept Mol Med & Pathol, Auckland 1, New Zealand

[5] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[6] Royal Childrens Hosp Melbourne, Infect Dis Unit, Parkville, Vic, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 01期

关键词：

streptococcus; toxin; nomenclature; toxic shock; invasive disease; INVASIVE GROUP-A; ACUTE RHEUMATIC-FEVER; HUMAN T-CELLS; PERIPHERAL-BLOOD LYMPHOCYTES; POLYMERASE-CHAIN-REACTION; EQUI SUBSP ZOOEPIDEMICUS; PYROGENIC EXOTOXIN-A; SHOCK-LIKE SYNDROME; HEART-DISEASE; MOLECULAR CHARACTERIZATION;

D O I：

10.1016/j.molmed.2013.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Superantigens are key virulence factors in the immunopathogenesis of invasive disease caused by group A streptococcus. These protein exotoxins have also been associated with severe group C and group G streptococcal infections. A number of novel streptococcal super-antigens have recently been described with some resulting confusion in their classification. In addition to clarifying the nomenclature of streptococcal superantigens and proposing guidelines for their categorization, this review summarizes the evidence supporting their involvement in various clinical diseases including acute rheumatic fever.

引用

页码：48 / 62

页数：15

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