Pathophysiology of Osteonecrosis of the Jaws

被引：129

作者：

Aghaloo, Tara ^{[1
]}

Hazboun, Renna ^{[2
,3
]}

Tetradis, Sotirios ^{[4
,5
]}

机构：

[1] Univ Calif Los Angeles, Sch Dent, Div Diagnost & Surg Sci, Sect Oral & Maxillofacial Surg, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Dent, Div Adv Prosthodont, Sect Special Patient Care, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Dent, Sect Restorat Dent, Div Regenerat & Constitut Sci, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Sch Dent, Div Diagnost & Surg Sci, Sect Oral & Maxillofacial Radiol, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA | 2015年 / 27卷 / 04期

关键词：

Osteonecrosis of the jaws (ONJ); Bisphosphonates; MRONJ; Antiresorptive; Pathophysiology; BISPHOSPHONATE-RELATED OSTEONECROSIS; MULTIPLE-MYELOMA PATIENTS; SURGEONS POSITION PAPER; ZOLEDRONIC ACID; BONE METASTASES; RISK-FACTORS; INDUCE OSTEONECROSIS; PERIAPICAL DISEASE; PROSTATE-CANCER; AMERICAN ASSOCIATION;

D O I：

10.1016/j.coms.2015.06.001

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Osteonecrosis of the jaw (ONJ) is a nnultifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms and extent of clinical and radiographic findings. Treatment strategies range from conservative local wound care to aggressive resective surgery of all necrotic bone. The first ONJ cases were reported in 2003 and 2004, and although significant progress has been made in our understanding of the disease, much more work needs to be done to completely explain its pathophysiology.

引用

页码：489 / +

页数：9

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