Antibacterial Application on Staphylococcus aureus Using Antibiotic Agent/Zinc Oxide Nanorod Arrays/Polyethylethylketone Composite Samples

被引：23

作者：

Chen, Dave W. ^{[1
,2
]}

Lee, Kuan-Yi ^{[1
,3
]}

Tsai, Min-Hua ^{[1
,3
]}

Lin, Tung-Yi ^{[1
,2
]}

Chen, Chien-Hao ^{[1
,2
]}

Cheng, Kong-Wei ^{[1
,3
]}

机构：

[1] Chang Gung Mem Hosp, Dept Orthopaed Surg, Keelung Branch, Taoyuan 204, Taiwan

[2] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[3] Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan 333, Taiwan

来源：

NANOMATERIALS | 2019年 / 9卷 / 05期

关键词：

antibacterial properties; zinc oxide; nanorods; polyetheretherketone (PEEK); ZNO NANORODS; HYDROTHERMAL SYNTHESIS; NANOPARTICLES; GROWTH; NANOTUBES; SUBSTRATE; EMISSION; IMPLANTS; PLATFORM; ARRAY;

D O I：

10.3390/nano9050713

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, zinc oxide (ZnO) nanorod arrays as antibiotic agent carriers were grown on polyetheretherketone (PEEK) substrates using a chemical synthesis method. With the concentration of ammonium hydroxide in the precursor solution kept at 4 M, ZnO nanorod arrays with diameters in the range of 100-400 nm and a loading density of 1.7 mg/cm(2) were grown onto the PEEK substrates. Their drug release profiles and the antibacterial properties of the antibiotic agent/ZnO/PEEK samples in the buffer solution were investigated. The results showed that the concentrations of antibiotic agents (ampicillin or vancomycin) released from the samples into the buffer solution were higher than the value of minimum inhibitory concentration of 90% for Staphylococcus aureus within the 96 h test. The bioactivities of ampicillin and vancomycin on substrates also showed around 40% and 80% on the Staphylococcus aureus, respectively. In the antibacterial activity test, sample with the suitable loading amount of antibiotic agent had a good inhibitory effect on the growth of Staphylococcus aureus.

引用

页数：15

共 43 条

[31] Ferric oxide nanoparticle-functionalized tungsten oxide nanoneedles and their gas sensing properties [J].