Distribution of serotonin 5-hydroxytriptamine 1B (5-HT1B) receptors in the normal rat hypothalamus

被引：48

作者：

Makarenko, IG

Meguid, MM

Ugrumov, MV

机构：

[1] SUNY Upstate Med Univ, Surg Metab & Nutr Lab, Program Neurosci, SUNY Univ Hosp,Dept Surg, Syracuse, NY 13210 USA

[2] Russian Acad Sci, Inst Dev Biol, Lab Hormonal Regulat, Moscow 117808, Russia

来源：

NEUROSCIENCE LETTERS | 2002年 / 328卷 / 02期

关键词：

5-hydroxytryptamine; brain; immunohistohemistry; double-labeling; magnocellular neurons; feeding;

D O I：

10.1016/S0304-3940(02)00345-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This is the study first attempting to evaluate distribution of neurons expressing serotonin 5-hydroxytriptamine 1B (5-HT1B) receptors in hypothalamus by using immunocytochemistry. The 5-HT1B-immunoreactive neurons were widely distributed in hypothalamus. Accumulations of 5-HT1B neurons occurred in magnocellular nuclei, supraoptic nucleus, paraventricular nucleus (dorsolateral part) and accessory perifornical, circular and retrochiasmatic nuclei. Magnocellular neurons manifested an intense immunostaining suggesting a high level of 5-HT1B receptors. Large and middle-sized neurons with different 5-HT1B staining patterns were scattered throughout lateral hypothalamus, periventricular nucleus and lateral preoptic area. Immunofluorescent double-labeling revealed a great overlapping of the distribution 5-HT1B neurons and dense network of neuropeptide Y-immunoreactive fibers in paraventricular, supraoptic and arcuate nuclei. The potential functional significance of 5-HT1B receptors in the 5-HT control of endocrine functions and feeding are discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 159

页数：5

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