Exploiting non-covalent π interactions for catalyst design

被引：655

作者：

Neel, Andrew J. ^{[1
,2
,4
]}

Hilton, Margaret J. ^{[3
]}

Sigman, Matthew S. ^{[3
]}

Toste, F. Dean ^{[1
,2
]}

机构：

[1] Lawrence Berkeley Natl Lab, Div Chem Sci, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Univ Utah, Dept Chem, 315 South 1400 East, Salt Lake City, UT 84112 USA

[4] Merck & Co Inc, Dept Proc Chem, Rahway, NJ 07065 USA

来源：

NATURE | 2017年 / 543卷 / 7647期

基金：

美国国家科学基金会;

关键词：

AROMATIC STACKING INTERACTIONS; LONE-PAIR; ASYMMETRIC CATALYSIS; AB-INITIO; SUPRAMOLECULAR COMPLEXES; TRANSFER HYDROGENATION; ENOLATE CHEMISTRY; SQUALENE CYCLASE; ANION-CATALYSIS; ACIDIC SURFACES;

D O I：

10.1038/nature21701

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Molecular recognition, binding and catalysis are often mediated by non-covalent interactions involving aromatic functional groups. Although the relative complexity of these so-called pi interactions has made them challenging to study, theory and modelling have now reached the stage at which we can explain their physical origins and obtain reliable insight into their effects on molecular binding and chemical transformations. This offers opportunities for the rational manipulation of these complex non-covalent interactions and their direct incorporation into the design of small-molecule catalysts and enzymes.

引用

页码：637 / 646

页数：10

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