Indirect T-cell allorecognition: Perspectives for peptide-based therapy in transplantation

Indirect allorecognition is nit important component of allotransplant rejection. Although the initial indirect alloresponse is limited to a fete dominant determinants on donor major histocompatibility complex (MHC) molecules, subsequent spreading to additional determinants on recipient and donor antigens is common. Gilles Benichou and colleagues discuss the mechanisms by which immunodominance is acquired or disrupted in indirect alloresponses, and examine the implications for the design of peptide-based selective immunotherapy in transplantation.